How Long Does Nicotine Stay in Your System

How nicotine affects your system?

Nicotine is an alkaloid which contains nitrogen chemical and also is found in some types of plants, such as red peppers, eggplant, tomatoes, particularly tobacco. It can also be synthesized artificially.

When you smoke tobacco leaves, including passive way, nicotine will be absorbed directly into your blood and it goes into your system. In some moments, through the smoke screen, you may ask yourself how the nicotine acts in your body.
Nicotine, Nicotine in Kidney, Blood, Urine, Saliva

In the blood, nicotine stimulates the liver secrets some enzymes which break nicotine into cotinine. The cotinine amount is depended on how much nicotine that you intake, also with the time which nicotine lasts in your system. After that, the kidneys will eliminate these substances through urine.

In the neurovascular system, nicotine takes only a few seconds to affect, it will stimulate special receptors which named nicotinic acetylcholine. Through that, the neurovascular will send a signal to release of many chemical substances which are acetylcholine, norepinephrine, epinephrine, and serotonin. Also, nicotine makes the effects of dopamine last longer in the body. That is the reason why smoking cigarette can promote brain performance, improving focus ability, memory, and reducing depression. Moreover, reducing hunger is a special effect of nicotine. Because of these effects to the neurovascular system, nicotine is considered as an addictive property which makes the smokers depend on products containing tobacco leaves.

In the cardiovascular, the release of norepinephrine and epinephrine from the neurovascular can increase the heartbeat which boosts more blood to the organs. Also, these substances from the neurovascular system will make the arteries and veins constrict, which leads to hypertension.

How long does nicotine stay in your blood?

In the bloodstream, nicotine lasts for three days, and for up to 10 days, nicotine still is identified in the blood.

The tests can detect both the existence of nicotine and how much nicotine in the blood. The tests have a very high accuracy but sometimes, false positives can happen because your blood can contain a substance called thiocyanate which is in some foods and medications.

How long does nicotine last in your urine?

The answer will depend on how much nicotine which you ingested and also how frequently you use products containing nicotine. In one cigarette, there are 12 milligrams of nicotine, commonly. However, the body only absorbs 1 mg of nicotine.

In the bloodstream, the average nicotine amount is normally higher than 10ng/mL or in some cases, it is up to 500ng/mL.

If you frequently smoke, also second-hand smoking, the nicotine will present for about four days in the urine and it can be detected after three weeks from the last exposure.

Nicotine urine test can provide the information of the presence of the nicotine in blood and how much nicotine stays in your urine. With a current smoker, the test can be positive at the level of 1000 ng/mL in the urine. If you have stopped to smoke for two weeks, at the level of 30 ng/mL, the test can be positive.

How long does nicotine stay in the saliva?

The fact is that the nicotine can stimulate the body to secrete more saliva than normal. From the last exposure to nicotine, chewing or smoking, nicotine can be detected in four days. However, the saliva nicotine test only can identify the trace of nicotine and for how much nicotine in the saliva, the test can not say.

What is the most common way to determine the presence of nicotine in your system?

The saliva test is the simple method which can answer whether nicotine was in your blood in a very short time. Also, it is very easy to conduct.

Factors influent how long nicotine stays in your system?

In some people, the nicotine stays in the body just in a very short time. On the other hand, nicotine can stay for months in some people. Some factors can affect the time and the amount of nicotine in the body.

Age: The younger you are, the faster nicotine can take the body to exclude. By contrast, if you were not young, it would take a longer time to remove all of the nicotine amounts in the body.

Hormones: There is a difference between women and men in nicotine metabolism. Nicotine stays in men longer than in women because of being the presence of estrogen, a hormone in women.

Liver function: Because the liver produces the enzymes to break down the nicotine so how long nicotine stays in your system will depend a lot on your liver function.

The frequency of smoking: This is absolutely a main factor which affects to how long does nicotine stay in the body. The more frequent you smoke, the longer time nicotine stays in your body.


Extracting nicotine from cigarette


  1. Nicotine is very addictive and it is the addictive substance in cigarettes, vapes or e-cigarettes. People use tobacco products, some of them contain nicotine and that nicotine stays in their system after they quit smoking . Medical tests can detect nicotine in people's urine, blood, saliva, hair, and nails.


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